The drug Regorafenib, a commonly used cancer drug, can cause unpleasant side effects. These range from mild nausea to hand and foot pain that makes walking or holding objects difficult. Richard Goldberg, the director of WVU’s Cancer Institute, is researching a treatment regimen that combines Regorafenib with another drug to halt the progression of colorectal cancer while also ameliorating these and other noxious side effects.

WVU Cancer Institute studies new treatment for colorectal cancer using novel drug combination

Once colorectal cancer invades another organ—the liver or lung, for instance—a cancer patient has about a 13 percent chance of living five more years.

Richard Goldberg, who directs the West Virginia University Cancer Institute, is searching for new ways to slow this cancer’s progression. In a recent study, he and an international team of scientists investigated a new drug combination for treating metastatic colorectal cancer in patients who had no—or only temporary—success with conventional chemotherapy treatments.

When a first-line chemotherapy regimen fails, a physician may follow up with a second-line treatment to attack the resistant or resurgent tumors. But when it comes to colorectal cancer, these second-line treatments halt the tumors’ growth and spread for just a few months, on average.

Goldberg and his colleagues wanted to stop the cancer’s growth for longer than that. They investigated whether combining a typical second-line treatment, called FOLFIRI, with another drug, called Regorafenib, was a safe and effective way to stall the cancer’s progression. Regorafenib had already been approved as a standalone treatment for colorectal cancer, but using it alongside FOLFIRI was novel.

Regorafenib was an attractive choice for the researchers because, rather than targeting a single enzyme in cancer cells, it targets multiple ones. “Regorafenib is something that we call a dirty kinase inhibitor,” explained Goldberg, the director of WVU’s Cancer Signature Program and the Laurence S. and Jean J. DeLynn Chair of Oncology. “Dirty kinase inhibitors are more advantageous in previously treated patients because, often, tumor cells will evolve along several different pathways. A drug that hits several pathways is potentially more useful.”

For their randomized, double-blind study, Goldberg and his team recruited 181 colorectal cancer patients with tumors that couldn’t be surgically removed, had spread to other parts of the body and had progressed after a first-line chemotherapy treatment. Some of the patients were randomly assigned to receive FOLFIRI—the standardly used second-line treatment—along with Regorafenib. Others were assigned to take FOLFIRI and a placebo pill.

Patients who received the new drug combination tended to have a longer interruption of their cancer progression. The median length of their progression-free survival was 6.1 months. Meanwhile, the patients who took a placebo remained progression-free a median of 5.3 months. In addition, patients who took both FOLFIRI and Regorafenib experienced a modest increase in overall survival.

The researchers also wanted to see if by using a lower dose of Regorafenib than is recommended when the drug is administered by itself could reduce the side effects patients experienced from the new drug combination while still slowing the cancer’s progression. Instead of prescribing 180 milligrams of Regorafenib, to be taken each day for two weeks, they prescribed a daily dose of 160 milligrams, to be taken for six days. “It actually turned out that it was relatively well tolerated by reducing the dose and duration of the Regorafenib,” said Goldberg, and we still saw an indication of increased efficacy.

“The approach that we took of administering a lower cumulative dose of Regorafenib led to additional studies that have made most oncologists start at a lower dose even when using the drug as a single treatment,” he added. “Our investigation has helped to change the approach to using this drug, to make it less intensive than it was originally.”

That’s important because the side effects of Regorafenib, even when it’s used alone, can be nasty. They range from mild nausea and diarrhea, to severe fatigue and hand-foot syndrome, a condition that can make someone’s palms and soles so tender that they have trouble washing dishes; using knives, can openers and gardening tools; or walking.

“I guess the 30,000-foot view on this is, when you get a new drug that shows activity, you try to look for ways of combining it with old drugs to exploit the value of it,” Goldberg said. “You have to balance the benefit, in terms of slowing tumor progression and improving survival, with quality of life. And that often takes experimentation. That’s why we do studies like this.”



Consolidated board determines North Kanawha will remain a two-way street

BUCKHANNON – The Consolidated Public Works Board voted to keep North Kanawha Street a two-way street after previously considering making it a one-way road. The CPWB took up two previously discussed traffic items during their Jan. 26 meeting. The board […]

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Barbour County man arrested for alleged sexual abuse of a juvenile in his care

BUCKHANNON — A Barbour County man who is listed on the West Virginia State Police’s Sex Offender Registry has been arrested for the alleged sexual abuse of a minor in his care. Kenneth D. Call, 52, of Belington, W.Va., was […]

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Buckhannon: Then & Now – Big snow in Upshur County

Buckhannon: Then & Now. Join us in showcasing Upshur County throughout history and today. Much like today, Buckhannon has experienced major snow accumulations throughout history. Pictured here, Buckhannon received a record breaking accumulation of 40

County commission tasks new owner of Holly Apartments with cleaning up the site, will reevaluate in 90 days

BUCKHANNON – The Upshur County Commission has given the new owners of the Holly Apartments building in Adrian 90 days to clean up the property. The Holly Apartments were considered a total loss after a fire spread throughout the whole […]

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B-U claims 11 conference titles, finishes second at Big 10 Swim Championships on Saturday

BRIDGEPORT — The Buckhannon-Upshur High School girls and boys swim teams collected 11 gold medals, two conference records and a second-place overall finish at the Big 10 Championships in Bridgeport on Saturday. The host Indians won the combined team event, […]

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Wesleyan lacrosse picked fifth in MEC preseason poll

BUCKHANNON, W.Va. – West Virginia Wesleyan women’s lacrosse has been selected to finish fifth in the Mountain East Conference, the league announced today. WVWC totaled nine points in the vote. Frostburg State and Notre Dame College tied

Swim Bucs head into Saturday’s conference championship meet coming off strong final performance at home

BUCKHANNON — The Buckhannon-Upshur High School boys and girls swim teams will head into the Big 10 Conference Championships on Saturday with the current at their backs after winning 10 events in their final home meet of the season. The […]

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Owens steps down as head coach of Lady Bobcat soccer program

BUCKHANNON, W.Va. – Richard Owens has resigned as head coach of the West Virginia Wesleyan women’s soccer program, WVWC Athletic Department announced on Thursday. Owens spent five seasons as head coach of the Lady Bobcats,


This Week in West Virginia History: Jan. 29 – Feb. 4

Charleston, WV – The following events happened on these dates in West Virginia history. To read more, go to e-WV: The West Virginia Encyclopedia at www.wvencyclopedia.org. Jan. 29, 1903: The great rhododendron was designated the